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KMID : 0880520200560010001
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Chonnam Medical Journal
2020 Volume.56 No. 1 p.1 ~ p.5
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Scavenger Receptor Class A to E Involved in Various Cancers
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Ryu Sun-Hyo
Howland Amanda
Song Brendon
Youn Cha-Kyung
Song Peter I.
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Abstract
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Scavenger receptors typically bind to multiple ligands on a cell surface, including endogenous and modified host-derived molecules and microbial pathogens. They promote the elimination of degraded or harmful substances such as non-self or altered-self targets through endocytosis, phagocytosis, and adhesion. Currently, scavenger receptors are subdivided into eight classes based on several variations in their sequences due to alternative splicing. Since recent studies indicate targeting scavenger receptors has been involved in cancer prognosis and carcinogenesis, we will focus on the current knowledge about the emerging role of scavenger receptor classes A to E in cancer progression.
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KEYWORD
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Scavenger Receptor, Scavenger Receptor Class A, Macrophages, Lectin-Like Oxidized LDL Receptor 1
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